Enrolling

CAMPFIRE: A Study of Abemaciclib (LY2835219) in Participants With Ewing's Sarcoma

J1S-MC-JP04 -

The purpose of this study is to measure the benefit of adding abemaciclib to chemotherapy (irinotecan and temozolamide) for Ewing's sarcoma that has come back or did not respond to treatment. This trial is part of the CAMPFIRE master protocol, which is a platform to speed development of new treatments for children and young adults with cancer.

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See if You May Qualify

Answer a few questions to see if you meet key criteria for this study.

Trial Summary

Age Range
1 year - 39 years
Conditions the trial is for
Ewing's Sarcoma
What the trial is testing?
Abemaciclib (LY2835219)
Could I receive a Placebo?
No
Enrollment Goal
45
Trial Dates
Sep 20, 2022 - Sep 2028
How long will I be in the trial?
Your participation in this trial could last 11 months or longer, depending on how you and your tumor respond.
Trial Phase
II

Key Requirements

Clinical trials have inclusion and exclusion requirements to determine which individuals qualify for participation. Listed below are key requirements for this clinical trial, but there may be additional requirements to qualify.

Participants Must:

  • Participants must have Ewing’s sarcoma or Ewing’s sarcoma-like cancer
  • Participants must have cancer that has gotten worse or has not responded to treatment
  • Participants must have stopped cancer treatments and recovered from the major side effects
  • Participants must be well enough to provide their own personal care most of the time
  • Participants must be able to swallow or have a feeding tube
  • Participants must have adequate organ function and blood counts, as measured by lab tests

Participants Must Not:

  • Participants must not have active infection or any serious medical conditions (other than this cancer)
  • Participants must not have received prior treatment with abemaciclib or other drugs that work in the same way
  • Participants must not be pregnant or breastfeeding

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