ASPHO Webinars Connect Learners to the Latest in Pediatric Hematology/Oncology Clinical Treatment, Best Practices, and Professional Development
ASPHO and its partners create presentations led by experts in clinical and career topics of broad interest to pediatric hematology/oncology specialists. Webinar attendees can participate live and ask presenters and moderators questions, or they can watch a recorded version after the event. Stay informed with convenient, on-demand education designed for today's pediatric hematology/oncology practitioner.
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About ASPHO Webinars
All webinars are available on-demand; free to members and available for purchase to nonmembers. Each webinar is an hour-long, with 45 minutes of lecture and 15 minutes of live Q&A. Past webinars can be accessed through the Knowledge Center.
2023 Webinar Series
Register for Upcoming Webinars
Vignettes of Vanquishing Vexing Variants
Tuesday, March 7 at 3 pm CT
- Melissa Rose, DO (moderator)
- Harry (Adrian) Lesmana, MD
- Elizabeth Varga MS, LGC
As next generation genetic sequencing of pediatric hematology and oncology patients has expanded, we have seen an increase in germline variants that aid in diagnosis and treatment. On the other hand, due to limited information surrounding variants, especially those affecting newly identified disease genes, clinicians are bombarded by a number of variants of uncertain significance (VUS). As we have come to appreciate the phenotypic variation of many genetic conditions, the interpretation of germline VUS presents a challenge. Lack of access to genetic services creates additional barriers in the interpretation of genetic results. Pediatric hematology-oncology physicians must know how to consider a VUS when managing patients. They must develop a foundation of knowledge regarding tools that can be utilized when considering whether a VUS is potentially an actionable variant. A webinar focused on best practices with examples of how to use public gene variation and disease-specific databases, in-silico predictive tools, and literature, in evaluating germline VUS is vital. The ability to answer questions such as allele frequency, the location of the VUS relative to splice junctions and function of the encoded protein, whether or not the involved amino acid is conserved, are first steps to understanding the meaning of a VUS.
- Discuss specific examples of how germline variants of uncertain significance (VUS) are of potential importance in diagnosis and management of pediatric hematology / oncology patients
- Discuss practical approaches and resources that can be leveraged in the interpretation of VUS (e.g., familial segregation, location of VUS, potential functional impact of VUS)
- Case-based (e.g., inherited bone marrow failure, myelodysplasia, cancer) discussion providing practical examples of available resources that can be leveraged in the interpretation of VUS
Hope And Realism: Partnering with Patients and Families who Hope for Cure Despite Poor Prognoses
Wednesday, April 26 at 3 pm CT
- Daniel Cannone, DO MS
- Erica C. Kaye, MD MPH
- Taylor Aglio, MD
For many children with advanced cancer and their families, hope is tenacious and inextricably linked to coping and resilience. Parents describe hope as "life-sustaining," persisting across the illness course, even at end of life. Unfortunately, many clinicians misinterpret hope as refusal to accept reality (e.g., "that family is in denial") or worry about enabling false hope. Clinicians also avoid disclosing big picture information about incurable disease in the setting of smaller uncertainties (e.g., "I don't know for sure, so I don't want to take away their hope"). In this session, we will review data demonstrating that transparent disclosure of poor prognosis does not diminish hope. We also will present findings from the "Hear Our Parent Experiences (HOPE)" forum, through which bereaved parents reconceptualized the meaning of hope in the setting of advanced or incurable disease. Whether wishing for a cure, a return to normalcy, or mitigation of suffering, parents unanimously emphasized hope as indispensable and coexisting simultaneously with prognostic awareness. We will present the HOPE forum's 12 recommendations to guide clinicians. Finally, we will introduce recent evidence-based communication strategies to support person-centered, honest, longitudinal sharing of prognostic information in the context of advancing pediatric cancer.
- Review the existing literature, anchored in the voices of patients with advanced cancer, families, and bereaved parents, which characterizes the tenacity and necessity of hope across the illness course.
- Describe a novel conceptual model co-designed by bereaved parents of children with cancer to reimagine the meaning and purpose of hope in the setting of incurable illness.
- Explain bereaved parents' recommendations to guide clinicians in navigating difficult conversations about advancing illness when parents continue to maintain hope.
- Consider and practice evidence-based communication strategies, including a "seed planting approach" to longitudinal prognostic disclosure, to support person-centered, honest sharing of information about prognosis in the context of advancing pediatric cancer.
Access Past Webinars On Demand
Recordings of all webinars can be accessed through the Knowledge Center.