In this issue
- President's Message
- Society News
- Membership Bulletin
- Case Quiz
- Conference Central
- Career Center
Denise Adams, MD, and Amy Billett, MD
The 2017 ASPHO Annual Meeting was a tremendous success with a record number of attendees and roughly 20 presentations with a focus on critical scientific breakthroughs presented by our pediatric hematology/oncology basic science leaders. The timing was appropriate as we witnessed the unanimous recommendation to the U.S. Food and Drug Administration for the approval of CAR-T cell therapy last month.
Thomas Kuhn introduced the term paradigm shift in his 1962 book The Structure of Scientific Revolutions. The concept of gene editing has existed for decades. Smithies, Capecchi, and Evans were jointly awarded the Nobel Prize in 2007 for their work developing gene targeting methodologies in mouse embryonic stem cells. However, genome editing has now “come of age” and is poised for translation into clinical medicine. Thus, it is imperative that all in our field understand what genome editing is, how it works, what its strengths are, and what its weaknesses are.
To that end, we would like to focus on one of the superb 2017 Annual Meeting sessions that highlighted the principles of genome editing. Dr. Mitchell Weiss from St. Jude Children’s Hospital introduced the session, followed by a discussion of the clinical application of genomic editing by Dr. Stuart Orkin from Harvard Medical School, and ending with the ethical and health policy implications by Dr. Christopher Scott from Baylor College of Medicine. We are in awe of the accomplishments of these basic scientists and thankful to them for sharing their knowledge with the entire ASPHO community. This knowledge of cutting-edge laboratory techniques is useful to enhance our understanding as it infiltrates translational medicine.
The basic goal of genomic editing is to alter the genomic DNA accurately and specifically to create disease models and correct deleterious mutations. The field of basic science has been transformed with these techniques, which, it is important to note, can be translated into clinical medicine with great potential for improvement of disease.
Amazingly, molecular scissors—programmable, engineered nucleases—are able to create site-specific double stranded breaks at desired locations in the genome. There are multiple nucleases than can be used including finger nucleases ZFNs, TALE nucleases, Meganucleases, and CRISPR-Cas nucleases. The latter has come to be favored; thus, we are now in the “CRISPER Craze” because it can be done quickly, cheaply, and easily by many.
There are multiple important considerations when using these tools:
- Two potential outcomes of double-stranded breaks: nonhomologous end joining versus homologous DNA repair (HDR). HDR is more specific and more desirable but is far less likely to occur.
- Therapeutic delivery: in vivo or ex vivo. Each comes with its own challenges.
- Off-target effects: measurement techniques exist, but there is much to learn. A very big concern is increasing the risk of clonal proliferation and, thus, the development of cancer.
These techniques are being studied in sickle cell disease and hemophilia and will be studied in other diseases soon. As Dr. Scott noted, ethical and social implications of somatic gene therapies and germline therapies need to be evaluated, but these developments will be instrumental in improving the outcomes of our patients. Thank you Drs. Weiss, Orkin, and Scott for your work and your commitment to the field of pediatric hematology/oncology.
When we started this column, we thought about trying to teach you more about genome editing ourselves. Then, we realized that such teaching is best done by the experts in the field. We strongly encourage everyone to listen to these amazing talks, "Basic Principles of Genome Editing."
Denise Adams and Amy Billett
Moving to the Fall of 2018
As the sponsoring organization for the pediatric hematology/oncology subspecialty fellowship Match with the National Resident Matching Program (NRMP), ASPHO assumes the responsibility for coordination. In the past few years, ASPHO has monitored the shift of pediatric subspecialties to a fall Match date. In May of this year, ASPHO was notified that hematology/oncology was the only pediatric subspecialty in the spring Match.
Therefore, based on feedback from all pediatric hematology/oncology program directors over the previous years and a recommendation by the training committee, the ASPHO Board has approved that pediatric hematology/oncology move to the Pediatric Subspecialties Fall Match beginning in 2018, for the class entering in July 2019.
An example of the updated Match schedule follows (based on 2017):
ERAS Opens: July 15
Match Opens: September 27
Rank Order List Opens: October 25
Quota Change Deadline: November 15
Rank Order List Deadline: November 29
Match Day: December 13
ASPHO is dedicated to providing the tools and resources necessary to aid in pediatric hematology/oncology training program successes and will continue to provide updates as information becomes available.
Mark your calendar for the first webinar in the 2017–2018 series, Billing and Coding for Optimal Reimbursement in the ICD-10 Era.
Billing and coding for optimal reimbursement are essential to a sustainable practice in pediatric hematology/oncology, whether in the community or academic setting. Many clinicians have learned this on the job without any formal education on optimal billing/coding methods for the myriad of complex medical issues that our patients face. In this webinar we will review general concepts in optimal reimbursement, with specific attention to differences in both geography and in practice size/scope (academic center, community practice, regional childrens' hospitals).
Users of this webinar will learn practical strategies that can immediately be applied to their practice setting. Speakers will review common scenarios including a high complexity medical decision making visit, a moderate, a low, and a minimal complexity visit. Each will provide examples of documentation they would like to see in order to bill at the specific level.
Speakers will provide a brief review of the different standards that institutions can choose from when setting up their requirements (the 1995 and the 1997 based standards) and why institutions use one over another.
- describe approaches to optimize reimbursement in your practice
- discuss the billing/coding implications of advanced practitioners in practice
- define basic billing/coding levels for outpatient visits
- define basic billing/coding levels for inpatient hospital stays
- discuss optimal billing for PHO procedures.
Mark your calendars for upcoming webinars!
- Wednesday, November 15, 2017: Impact of Obesity on Outcomes in Childhood ALL Survivors
- Tuesday, January 23, 2018: Neonatal Thromboembolism: Management Challenges and Potential Solutions
- Thursday, March 15, 2018: Essentials of Mentorship
Please consider nominating your colleagues for the following ASPHO awards, which will be presented at the 2018 Annual Meeting in Pittsburgh, PA, May 2–5, 2018. The deadline to submit a nomination is Monday, August 7, at 2:59 pm PDT.
- Frank A. Oski Memorial Lectureship Award―Awarded to an outstanding clinical or laboratory investigator whose cutting-edge research is of the stature of the work completed by Dr. Oski.
- George R. Buchanan Lectureship Award―Granted to a nationally and/or internationally recognized pediatric hematologist/oncologist with significant research, education, and clinical expertise.
- Distinguished Career Award―Presented to a senior physician or other professional who has had a major impact in the subspecialty through some combination of research, education, patient care, and advocacy.
Your colleagues can join the ranks of 2017’s award recipients, Drs. Alexis A. Thompson (Oski), Jeffrey M. Lipton (Buchanan), and Holcombe E. Grier (Distinguished Career). Consider nominating those individuals whom you believe have made an impact and advancements in your profession!
Information regarding each award can be found on the ASPHO website.
Review the status of bills that ASPHO is a part of on the ASPHO Legislative Tracking Chart. Visit ASPHO’s Health Policy & Advocacy webpage to learn more about ASPHO’s advocacy efforts and look out for the quarterly ASPHO Advocacy Brief.
Are you attending the 2017 Children’s Oncology Group (COG) meeting September 12–15 in Atlanta? ASPHO and COG will be presenting “Recent Advances in the Understanding and Treatment of Pediatric CNS Malignancies” on Thursday, September 14 at 10 am.
Stop by the ASPHO booth to learn about ASPHO's education programs and upcoming events!
Are you planning to take the American Board of Pediatrics (ABP) Subspecialty Certification Examination? Do you need to review Part 3 of the ABP Maintenance of Certification in a Subspecialty Program? As a fellow in training or practitioner would you benefit from reviewing established standards of care?
Purchase your copy of ASPHO's 2017 Online Review Course and study at your own pace! The online course features 26 lectures presented at the February 2017 live review course and includes more than 300 sample questions with two slide review sessions on peripheral blood and bone marrow morphology as a special bonus. The online course gives you unlimited access through March 29, 2019, and you can earn up to 25 AMA PRA Category 1 Credits™.
The Advanced Practice Provider SIG (APP SIG) was formed in 2016 as a forum for the exchange of ideas and information among individuals with advanced degrees, including nurse practitioners, clinical nurse specialists, and physician assistants, as well as the promotion of their role in the field of pediatric hematology/oncology.
The APP SIG had its second meeting at the 2017 ASPHO Annual Meeting in Montréal. The SIG has already showed tremendous growth, with attendance nearly tripling from our inaugural year to about 50 attendees. Prior to the meeting in Montréal, the SIG chairs surveyed the community to gather demographic information as well as to identify needs of its members. The results showed significant interest in advocacy, collaboration, and mentorship, to name just a few. In the coming months to years, the SIG will focus its efforts on these and other topics while also developing specific didactic content as desired by its members.
We had a productive open discussion at the annual meeting, where attendees shared current practice issues, projects for which they were seeking input and collaboration, and how best to utilize the SIG. The feedback was overall very positive regarding the creation of this community and recognition of this unique, but vital, subspecialty within ASPHO.
Going forward, we will continue to encourage APP members of ASPHO to join the online community as this is our primary mode of communication as well as an excellent forum for sharing of ideas. We will continue to develop programming for both the onsite meetings as well as the online community in the interim and continue to strive to meet the needs of our members.
Each of ASPHO’s seven SIGs has an online community that is open to all members for year-round collaboration. These SIG communities serve as a forum for developing resource bases and gaining insight on specialized topics within the field. Learn more about ASPHO’s SIGs or go directly to the online Member Community to join one!
ASPHO extends a hearty welcome to new first-year fellows and recent Fellowship graduates who are joining your institution this fall. We hope you encourage these early career professionals to join ASPHO so they can benefit from important networking, education, and career resources. ASPHO membership gives new professionals
- clinical case insights through the online member community,
- discounts on education programs,
- opportunities to develop leadership skills,
- updates on key developments in the field, and
- a network of 2,000 peers, thought leaders and experts in the field.
Membership for first- through third-year trainees is complimentary and automatically renews during the 3-year fellowship program. A group application makes it easy to enroll multiple fellows from the same institution. Our Member Services team also can assist you by e-mail or phone at 847.375.4716 from 8 am to 5 pm CT.
Recent fellowship graduates also benefit immensely from Society membership available at a special rate. One-year post fellowship members can join for just $120, which includes a subscription to the Pediatric Blood & Cancer journal.
Help the newest members on your team start their career in the right direction by joining the ASPHO community.
Welcome to the new Comings & Goings section where members are invited to share career changes in their position, department and institution. To announce your career news, send us the Comings & Goings form by the 15th of the month before the next bimonthly issue of eNews. Remember to update your member profile!
ASPHO is pleased to share the 2016 Annual Report with members.
Read the full report for a recap of last year's highlights.
Stay connected with your colleagues with ASPHO's online communities.
Get clinical insights, share information, and collaborate on ASPHO’s popular and practical member community. Take a minute to visit ASPHO’s Facebook page to see articles, legislative updates, and other news about the field. Enjoy the #WEAREASPHO Member Moments profiles and photos from the 2017 Annual Meeting in Montréal!
A 16-Year-Old Male with Iron Deficiency Anemia: The Essential Part of the Matter
Kaitlin Stanley, MD, and Erika Friehling, MD
A 16-year-old previously healthy young man presented to the emergency room with fatigue, headaches and pallor. He endorsed a history of black, tarry stool and early satiety for several months. His maternal family history was not significant, and paternal history was unknown. On physical exam, he was pale and was noted to have a systolic flow murmur. There was no organomegaly, and an abdominal mass was not palpable.
The 2018 Annual Meeting will be held May 2–5, 2018, in Pittsburgh, PA. Round out your trip and see what Pittsburgh has to offer! This city is more than just the city of bridges. There are historical museums, sightseeing tours, art and culture, sports, and a variety of delicious food choices. Learn more about Pittsburgh.
The ASPHO Annual Meeting Committee invites the submission of abstracts for papers and posters to be presented at the 2018 Annual Meeting on May 2–5, 2018.
The call opens October 17, 2017, and closes January 9, 2018.
Abstracts must be original basic, clinical, or social science abstracts that relate to the field of pediatric hematology/oncology.
Submitted abstracts should focus on a topic such as hemostasis, thrombosis, vascular biology, case studies, red cells, hematology, leukemia solid tumors, bone marrow transplant, quality improvement, or outcomes research.
Now available, the 2017 Annual Meeting online recording is a valuable reference compiling 49 hours of synchronized audio recordings and slides for 28 paper sessions, 25 educational sessions, and presentations by award recipients. Available in a streaming format, the recording can be purchased for $149 by calling Member Services at 847.375.4716 or placing an order online.
Visit the Career Center Today
Visit ASPHO’s popular Career Center to stay on top of job openings in the field. The Career Center is the go-to source for employment and targeted recruitment opportunities in pediatric hematology/oncology.